Comprehensive Analysis of the Expression and Clinical Significance of a Ferroptosis-Related Genome in Ovarian Serous Cystadenocarcinoma: A Study Based on TCGA Data

Background: Epithelial ovarian cancer (EOC) is the deadliest malignancy among gynecologic tumors, and serous cystadenocarcinoma (OV) dominant histological type. Ferroptosis a novel iron-dependent, programmed form of cell death, agents that trigger ferroptosis may constitute potential anti-cancer therapies. Materials Methods: We herein extracted genes participate in process from online FerrDb database to create ferroptosis-related genome (FRG), then comprehensively analyzed relationship between mRNA expression each gene clinicopathologic features The Cancer Genome Atlas (TCGA)-OV cohort. Results: found most FRG were differently expressed OV normal tissue significantly related prognosis OV. In addition, ontology (GO) analysis revealed candidate primarily associated with responses nutrient levels, oxidative stress, oxygen neuronal death. Kyoto Encyclopedia Genes Genomes (KEGG) indicated ferroptosis, hepatitis B, mitophagy, prostate cancer, bladder cancer. protein–protein interaction (PPI) network exhibited 132 nodes, 565 edges, an average node degree 9.94, local clustering coefficient 0.539, indicating proteins closely interrelated one another biological cluster. A comprehensive top 5 involved promoting preventing these tissue, OV, reflected excellent diagnostic value, correlated immune infiltration tumor microenvironment (TME), polarization macrophages, checkpoints. protein levels differentially constitutively tissues tumors. Conclusions: ascertained majority was prognosis, dysregulation appeared influence development progression showed value for we postulate it checkpoints TME. posit targeting might comprise therapy